The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct AFM visualization of variant chromatin
نویسندگان
چکیده
Université de Lyon; Laboratoire Joliot-Curie, CNRS USR 3010, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07, France ; Université de Lyon; Laboratoire de Physique, CNRS UMR 5672, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07, France ; Université de Lyon; Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR 5239, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364 Lyon Cedex 07, France ; CNRS/UJF, Laboratoire de Spectrométrie Physique, UMR 5588, BP87, 140 Av. de la Physique, 38402 St. Martin d'Hères Cedex, France Charles University in Prague, Institute of Cellular Biology and Pathology, First Faculty of Medicine, and Department of Cell Biology, Institute of Physiology,Academy of Sciences of the Czech Republic, Albertov 4, 128 01 Prague 2, Czech Republic Université Joseph Fourier-Grenoble 1; INSERM Institut Albert Bonniot U823, Site Santé, BP 170, 38042 Grenoble Cedex 9, France.
منابع مشابه
The dynamics of individual nucleosomes controls the chromatin condensation pathway: direct atomic force microscopy visualization of variant chromatin.
Chromatin organization and dynamics is studied at scales ranging from single nucleosome to nucleosomal array by using a unique combination of biochemical assays, single molecule imaging technique, and numerical modeling. We show that a subtle modification in the nucleosome structure induced by the histone variant H2A.Bbd drastically modifies the higher order organization of the nucleosomal arra...
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